Studies on the Source of Urea Carbon

Author: Paigen, Kenneth

Year: 1951

Degree: Dissertation (Ph.D.)

Advisor: Borsook, Henry

Committee Member: Unknown, Unknown

Option: Biochemistry; Chemistry

DOI: 10.7907/WV7D-FW20

Abstract

A method has been devised for the testing of any substance as an intermediate in a reaction sequence. Using this technique, thirty-three substances have been tested as precursors of the urea carbon atom. Of the compounds tested, only citrulline and arginine were precursors.

Garbamyl L-glutamic acid was shown not to be a donor of the urea carbon, although it does have some function in urea synthesis.

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