I. Hapten Inhibition Studies with a Series of Local Anesthetics Derived from Piperidino Alcohols. II. The Incorporation of C¹⁴-Carboxyl-Labeled Leucine by Serum Proteins

Author: Bulman, Norman

Year: 1952

Degree: Dissertation (Ph.D.)

Advisors: Campbell, Dan Hampton; Pauling, Linus

Committee Member: Unknown, Unknown

Option: Chemistry; Physics

DOI: 10.7907/S9G7-0786

Abstract

Part I

Rabbit antibodies specific for the 3-(2-methyl-piperidino)propyl-p-aminobenzoate group have been prepared and the inhibition of precipitation of these antibodies has been studied. It was found that a series of local anesthetics derived from piperidino alcohols were effective inhibitors of precipitation in this system. Reasonable explanations of the serological properties of these drugs have been given but it has not been found possible to establish any relation between their serological properties and their pharmacological properties.

Part II

C14-carboxyl-labeled leucine has been administered to immunized rabbits. While receiving the labeled amino acid they also received intravenous injections of different antibody solutions. It was found that the normal constituents of the serum incorporated the radioactivity to any marked extent or else did so only upon the loss of their specific antibody characteristics.

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