Applications of the Enantioselective Allylic Alkylation Toward the Synthesis of Complex Natural Products

Author: Loskot, Steven Anthony

Year: 2019

Degree: Dissertation (Ph.D.)

Advisor: Stoltz, Brian M.

Committee Members: Reisman, Sarah E.; Stoltz, Brian M.; Grubbs, Robert H.; Agapie, Theodor

Option: Chemistry

DOI: 10.7907/TZHG-9B35

Abstract

The Stoltz group, and moreover the synthetic community at large, has long been interested in the development of methods for the synthesis of enantioenriched all-carbon quaternary stereocenters. This thesis present three projects all unified by the development and use of the palladium-catalyzed decarboxylative allylic alkylation to synthesize enantioenriched all-carbon quaternary stereocenter containing cyclopentanones as well as the natural product total synthesis.

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