Nickel-Catalyzed Electroreductive Cross-Coupling Reactions of Anhydrides and Alkyl Halides

Author: Chang, Daniel Kwon

Year: 2022

Degree: Master's thesis

Advisor: Reisman, Sarah E.

Committee Member: None, None

Option: Chemistry

DOI: 10.7907/w0pr-fs28

Abstract

The formation of new carbon–carbon bonds is one of the most important transformations in organic chemistry due to its ability to build the backbone of organic molecules. Nickel-catalyzed reductive cross-coupling reactions have recently emerged as an efficient and powerful strategy for the creation of new carbon–carbon bonds. Furthermore, electrochemistry can be harnessed to overcome some of the challenges encountered in many of the reductive cross-coupling reactions in the literature. Herein, we discuss the development of a new electroreductive nickel-catalyzed cross-coupling of anhydrides with unactivated alkyl bromides in collaboration with Amgen to produce large amounts of substituted cyclobutane products.

Files