I. Studies on the Synthesis, Resolution, and Properties of Some Fluorinated Amino Acids. II. Studies on Blood Group-A-Specific Substance. III. Systematic Qualitative Tests for Certain Acidic Elements in Organic Compounds. IV. Isolation of Compounds Toxic to Tomato Plants from Thamnosma montana

Author: Bennett, Edward Leigh

Year: 1949

Degree: Dissertation (Ph.D.)

Advisor: Niemann, Carl G.

Committee Member: Unknown, Unknown

Option: Chemistry; Biology

DOI: 10.7907/npzt-sm68

Abstract

I. Syntheses are described of the following fluorinated amino acids: ortho-, meta-, and para-fluorophenylalanine, 2-fluoro-4-methoxy-phenylalanine and 2-fluorotyrosine.

The apparent dissociation constants of the above mentioned phenylalanine derivatives have been determined by electrometric titration. The ultra-violet absorption spectra of the mono-fluorophenylalanines and fluorotyrosines have been obtained.

A study has been made of the factors influencing the asymmetric specificity of the papa.in catalyzed synthesis of amides.

The attempted preparation of fluorocyclohexanol is described.

II. Studies on blood group A-specific substance have been made. These include a study of methods of isolation, a study of the electrophoretic properties of blood group A-specific substance, and a colorimetric method for the estimation of the activity of substances inhibiting the isoagglutination of blood group A-cells. Also the appearance of sheep cell lysins and human A-cell agglutinins in rabbits immunized with a partially purified blood group A-specific substance from hog gastric mucin has been observed.

III. Qualitative tests for certain inorganic elements (and carbon) in organic compounds are described.

IV. A survey of desert shrubs for materials toxic to tomato seedlings grown in nutrient culture has been made. From Thamnosma montana three crystalline compounds toxic to tomato seedlings have been isolated.

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