Conformational Aspects of Valinomycin by ¹H and ¹³C Nuclear Magnetic Resonance

Author: Macmurchie, Donald David

Year: 1973

Degree: Dissertation (Ph.D.)

Advisor: Raftery, Michael A.

Committee Member: Unknown, Unknown

Option: Chemistry

DOI: 10.7907/AA4Y-Z215

Abstract

The conformation of valinomycin and its complex with potassium ion has been investigated by spectroscopic means and a plausible structure for the complex has been put forward. The essential features of the complex structure are consistent with the spectral data and the conformation in the crystal state. Inconsistencies between the spectral observations and crystal structure analysis of non-complexing valinomycin may be resolved if a rapid conformation equilibrium in solution is postulated; evidence for this process is discussed. The characteristics of valinomycin are compatible with an independent mechanism of ion transport.

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