Computational Microscopy: Turning Megapixels into Gigapixels

Author: Horstmeyer, Roarke William

Year: 2016

Degree: Dissertation (Ph.D.)

Advisor: Yang, Changhuei

Committee Members: Yang, Changhuei; Tropp, Joel A.; Vaidyanathan, P. P.; Hassibi, Babak; Zheng, Guoan

Option: Electrical Engineering

DOI: 10.7907/Z95Q4T1W

Abstract

The layout of a typical optical microscope has remained effectively unchanged over the past century. Besides the widespread adoption of digital focal plane arrays, relatively few innovations have helped improve standard imaging with bright-field microscopes. This thesis presents a new microscope imaging method, termed Fourier ptychography, which uses an LED to provide variable sample illumination and post-processing algorithms to recover useful sample information. Examples include increasing the resolution of megapixel-scale images to one gigapixel, measuring quantitative phase, achieving oil-immersion quality resolution without an immersion medium, and recovering complex three dimensional sample structure.

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